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2015-2020

Great discovers come from great teams...

THREE-DIMENSIONAL GENOMIC STRUCTURE AND COHESIN OCCUPANCY CORRELATE WITH TRANSCRIPTIONAL ACTIVITY DURING SPERMATOGENESIS (2019)

Covadonga Vara, Andreu Paytuví-Gallart, Yasmina Cuartero, et al.

Cell Rep​. 2019 Jul 9;28(2):352-367.e9.

 doi: 10.1016/j.celrep.2019.06.037.

EPIGENETIC LOSS OF THE ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION INHIBITOR SVIP INDUCES CANCER CELL METABOLIC REPROGRAMMING (2019)

Pere Llinàs-Arias, Margalida Rosselló-Tortella, Paula López-Serra, et al.

JCI Insight​. 2019 Mar 7;5(8):e125888.

 doi: 10.1172/jci.insight.125888.

GERMLINE VARIATION IN O 6-METHYLGUANINE-DNA METHYLTRANSFERASE (MGMT) AS CAUSE OF HEREDITARY COLORECTAL CANCER (2019)

Sami Belhadj*, Cátia Moutinh*o, Pilar Mur, et al.

Cancer Lett​. 2019 Apr 10;447:86-92.

 doi: 10.1016/j.canlet.2019.01.019. Epub 2019 Jan 21.

TUTORIAL: GUIDELINES FOR THE EXPERIMENTAL DESIGN OF SINGLE-CELL RNA SEQUENCING STUDIES (2018)

Atefeh Lafzi*, Catia Moutinho*, Simone Picelli, et al.

Nat Protoc. 2018 Dec;13(12):2742-2757.
doi: 10.1038/s41596-018-0073-y.

IN VITRO AND IN VIVO ACTIVITY OF A NEW SMALL-MOLECULE INHIBITOR OF HDAC6 IN MANTLE CELL LYMPHOMA (2018)

Montserrat Pérez-Salvia, Eneko Aldaba, Yosu Vara, et al.

Haematologica. 2018 Nov;103(11):e537-e540.
doi:10.3324/haematol.2018.189241. Epub 2018 Jun 7.

ORTHOXENOGRAFTS OF TESTICULAR GERM CELL TUMORS DEMONSTRATE GENOMIC CHANGES ASSOCIATED WITH CISPLATIN RESISTANCE AND IDENTIFY PDMP AS A RESENSITIZING AGENT (2018)

Josep M Piulats, August Vidal, Francisco J García-Rodríguez, et al.

Clin Cancer Res. 2018 Aug 1;24(15):3755-3766. doi: 10.1158/1078-0432.CCR-17-1898. Epub 2018 Apr 4.

BROMODOMAIN INHIBITION SHOWS ANTITUMORAL ACTIVITY IN MICE AND HUMAN LUMINAL BREAST CANCER (2017)

Montserrat Pérez-Salvia, Laia Simó-Riudalbas, Pere Llinàs-Arias, et al.

Oncotarget. 2017 May 29;8(31):51621-51629. doi:10.18632/oncotarget.18255. eCollection 2017 Aug 1.

EPIGENETIC LOSS OF THE RNA DECAPPING ENZYME NUDT16 MEDIATES C-MYC ACTIVATION IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (2017)

C Anadón, G van Tetering, H J Ferreira, et al.

Leukemia. 2017 Jul;31(7):1622-1625.
doi: 10.1038/leu.2017.99. Epub 2017 Mar 27.

DNMT3A MUTATIONS MEDIATE THE EPIGENETIC REACTIVATION OF THE LEUKEMOGENIC FACTOR MEIS1 IN ACUTE MYELOID LEUKEMIA (2017)

H J Ferreira, H Heyn, M Vizoso, et al.

Oncogene​. 2017 Jul 20;36(29):4233.

 doi: 10.1038/onc.2017.57. Epub 2017 Mar 13. CORRIGENDUM 2017

MICRORNAS AND EPIGENETICS (2017)

Catia Moutinho, Manel Esteller

Adv Cancer Res​. 2017;135:189-220.

 doi: 10.1016/bs.acr.2017.06.003.

EPIGENETIC INACTIVATION OF THE P53-INDUCED LONG NONCODING RNA TP53 TARGET 1 IN HUMAN CANCER (2016)

Angel Diaz-Lagares, Ana B Crujeiras, Paula Lopez-Serra, et al.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7535-E7544.

 doi: 10.1073/pnas.1608585113. Epub 2016 Nov 7.

EPIGENETIC PROFILING TO CLASSIFY CANCER OF UNKNOWN PRIMARY: A MULTICENTRE, RETROSPECTIVE ANALYSIS (2016)

Sebastian Moran, Anna Martínez-Cardús, Sergi Sayols, et al.

Lancet Oncol. 2016 Oct;17(10):1386-1395. doi: 10.1016/S1470-2045(16)30297-2. Epub 2016 Aug 27.

EPIGENETIC HOMOGENEITY WITHIN COLORECTAL TUMORS PREDICTS SHORTER RELAPSE-FREE AND OVERALL SURVIVAL TIMES FOR PATIENTS WITH LOCOREGIONAL CANCER (2016)

Anna Martínez-Cardús, Sebastian Moran, Eva Musulen, et al.

Gastroenterology. 2016 Nov;151(5):961-972.
doi: 10.1053/j.gastro.2016.08.001. Epub 2016 Aug 10.

MECHANISMS OF THERAPY RESISTANCE IN PATIENT-DERIVED XENOGRAFT MODELS OF BRCA1-DEFICIENT BREAST CANCER (2016)

Petra Ter Brugge, Petra Kristel, Eline van der Burg, et al.

J Natl Cancer Inst​. 2016 Jul 5;108(11).

 doi: 10.1093/jnci/djw148. Print 2016 Nov.

GENE AMPLIFICATION-ASSOCIATED OVEREXPRESSION OF THE RNA EDITING ENZYME ADAR1 ENHANCES HUMAN LUNG TUMORIGENESIS (2015)

C Anadón, S Guil, L Simó-Riudalbas, et al.

Oncogene​. 2016 Aug 18;35(33):4407-13.

 doi: 10.1038/onc.2015.469. Epub 2015 Dec 7.

TUMOR MGMT PROMOTER HYPERMETHYLATION CHANGES OVER TIME LIMIT TEMOZOLOMIDE EFFICACY IN A PHASE II TRIAL FOR METASTATIC COLORECTAL CANCER (2016)

A Amatu, L Barault, C Moutinho , et al.

Ann Oncol​. 2016 Jun;27(6):1062-1067.

 doi: 10.1093/annonc/mdw071. Epub 2016 Feb 24.

TARGETING GLUCOSYLCERAMIDE SYNTHASE UPREGULATION REVERTS SORAFENIB RESISTANCE IN EXPERIMENTAL HEPATOCELLULAR CARCINOMA (2016)

Milica Stefanovic, Anna Tutusaus, Guillermo A Martinez-Nieto, et al.

Oncotarget​. 2016 Feb 16;7(7):8253-67.

 doi: 10.18632/oncotarget.6982.

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EPIGENETIC INACTIVATION OF THE PUTATIVE DNA/RNA HELICASE SLFN11 IN HUMAN CANCER CONFERS RESISTANCE TO PLATINUM DRUGS (2016)

Vanesa Nogales , William C Reinhold , Sudhir Varma, et al.

Oncotarget. 2016 Jan 19;7(3):3084-97.

 doi: 10.18632/oncotarget.6413.

MUTATIONS IN JMJD1C ARE INVOLVED IN RETT SYNDROME AND INTELLECTUAL DISABILITY (2016)

Mauricio A Sáez, Juana Fernández-Rodríguez, Catia Moutinho, et al.

Genet Med​. 2016 Apr;18(4):378-85.

 doi: 10.1038/gim.2015.100. Epub 2015 Jul 16.

KAT6B IS A TUMOR SUPPRESSOR HISTONE H3 LYSINE 23 ACETYLTRANSFERASE UNDERGOING GENOMIC LOSS IN SMALL CELL LUNG CANCER (2015)

Laia Simó-Riudalbas, Montserrat Pérez-Salvia, Fernando Setien, et al.

Cancer Res​. 2015 Sep 15;75(18):3936-45.

 doi: 10.1158/0008-5472.CAN-14-3702. Epub 2015 Jul 24.

TUMOR-RELATED MOLECULAR MECHANISMS OF OXALIPLATIN RESISTANCE (2015)

Eva Martinez-Balibrea, Anna Martínez-Cardús, et al.

Mol Cancer Ther. 2015 Aug;14(8):1767-76. doi: 10.1158/1535-7163.MCT-14-0636. Epub 2015 Jul 16.

DIGITAL PCR QUANTIFICATION OF MGMT METHYLATION REFINES PREDICTION OF CLINICAL BENEFIT FROM ALKYLATING AGENTS IN GLIOBLASTOMA AND METASTATIC COLORECTAL CANCER (2015)

L Barault, A Amatu, F E Bleeker, et al. 

Ann Oncol. 2015 Sep;26(9):1994-1999.

 doi: 10.1093/annonc/mdv272. Epub 2015 Jun 25.

EPIGENETIC ACTIVATION OF A CRYPTIC TBC1D16 TRANSCRIPT ENHANCES MELANOMA PROGRESSION BY TARGETING EGFR (2015)

Miguel Vizoso, Humberto J Ferreira, Paula Lopez-Serra, et al.

Nat Med. 2015 Jul;21(7):741-50.

 doi: 10.1038/nm.3863. Epub 2015 Jun 1.

HEAD-TO-HEAD ANTISENSE TRANSCRIPTION AND R-LOOP FORMATION PROMOTES TRANSCRIPTIONAL ACTIVATION (2015)

Raquel Boque-Sastre, Marta Soler, Cristina Oliveira-Mateos , et al.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5785-90.
doi: 10.1073/pnas.1421197112. Epub 2015 Apr 22.